Regioselective Preparation of 2-Phenylethylamines from 1-Phenyl-2-alkyl- alkynes by Hydroamination/Reduction Sequences
نویسندگان
چکیده
SYNTHESIS 2004, No. x, pp 000A–000Exx.xx.2004 Advanced online publication: xx.xx.2004 DOI: 10.1055/s-2004-834863; Art ID: Z15004SS © Georg Thieme Verlag Stuttgart · New York Abstract: Ind2TiMe2 is a highly active and general catalyst for the intermolecular hydroamination of alkynes. Particularly impressive is that Ind2TiMe2 makes it possible to perform hydroamination reactions of unsymmetrically substituted 1-phenyl-2-alkylalkynes with primary aryl-, tert-alkyl-, sec-alkyl-, and n-alkylamines in a highly regioselective fashion. Since the initially formed imines can easily be reduced with zinc-modified NaBH3CN, 2-phenylethylamines are accessible in reliable one-pot procedures from 1-phenyl-2-alkylalkynes and primary amines on a 10 mmol scale.
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